α2-Macroglobulin

α2-Macroglobulin

Synonyms α2-M;α2-Macroglobulin

CAS Number: Not applicable

MDL Number: MFCD00130472

Packaging size: 5 mg

SKU 0219134505
Price:
$726.25
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Description

Product Description

α2-Macroglobulin

Application Notes

α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibitor

Specifications
SKU 0219134505
Alternate Names α2-M;α2-Macroglobulin
Analysis Note Prepared from plasma that was shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Application Notes α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.
Biochemical Physiological Actions One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein. α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Format Crystalline powder
Formulation Details Lyophilized from 490 µL 30 mM Na phosphate; pH 7.0 and 10 mg Glucine and 1 mg glycine.
Applications Inhibitor
MDL # MFCD00130472
Pack Size 5 mg
Physical Appearance White Crystalline Powder
Product Families Description α-2-Macroglobulin
Product Overview α2-Macroglobulin
Purity ≥95% (SDS-PAGE)
Source Human plasma
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.