Catalase--N/H (Dry Ice)
Catalase occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.It promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.Defects in catalase are the cause of acatalasemia,a metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
|Alternate Names||H2O2:H2O2 oxidoreductase|
|Biochemical Physiological Actions||Catalase activates the decomposition of hydrogen peroxide, a reactive oxygen species, into water and oxygen. It functions as a natural antioxidant, protecting cells against oxidative damage to proteins, lipids and nucleic acids. Catalase has also been used to study the role reactive oxygen species play in gene expression and apoptosis.|
|Format||Supplied as frozen solution of 1mg/mL in 1.5mM sodium phosphate; 20mM NaCl; pH 7.0 composed of four identical subunits. Negative for HBsAg and HIV antibodies.|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Physical Appearance||Frozen Solution|
|Storage and Handling||Store at -20 °C.|
|Unit Definition||One unit is defined as the amount of enzyme that will decompose 1 μmole of H2O2 per minute at 25 °C, pH 7.0.|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|