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Aldehyde Dehydrogenase

Aldehyde Dehydrogenase

Synonyms Aldehyde:NAD[P]+ oxidoreductase; ALDH

CAS Number: 9028-86-0

EC Number: 232-845-3 MDL Number: MFCD00081306

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SKU 02190679-CF
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Description

Product Description

Aldehyde Dehydrogenase

Application Notes

Aldehyde dehydrogenase oxidizes a number of aliphatic and aromatic aldehydes. Acetyl-GSH is not hydrolyzed.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Acting on aldehydes or oxo groups

Specifications
SKU 02190679-CF
Application Notes Aldehyde dehydrogenase oxidizes a number of aliphatic and aromatic aldehydes. Acetyl-GSH is not hydrolyzed.
Biochemical Physiological Actions Aldehyde dehydrogenase is a tetramer and has several different isoforms. The enzyme tested in 0.01 M pyrophosphate buffer shows a sharp optimum around pH 9.3 with acetaldehyde as substrate. Potassium ions and cysteine are essential for the enzyme's activity. Rubidium or NH4+ can be substituted for K+, and glutathione for cysteine. Lithium, Na+, and Cs+ inhibit the reaction. Aldehyde dehydrogenase is inhibited by propylurea, crotonaldehyde, n-propyl isocyanate, cyclohexyl isocyanate, 1-n-propyl-1-[(4-chlorophenyl)sulphonyl]-3-n-propylurea, and 1-methyl-1-[(4-chlorophenyl)sulphonyl]-3-n-propylurea. The enzyme may be utilized to quantitate aldehydes present in blood.
EC Number 232-845-3
Extinction Coefficient 9.4 (279 nm)(Lit)
Format Potassium Activated; Freeze dried stabilized powder
Gene ID 855205
Applications Acting on aldehydes or oxo groups
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance Off-white Powder
Product Families Description Aldehyde Dehydrogenase
Product Overview Aldehyde Dehydrogenase
Source Yeast
Specific Activity Protein-~5 u/mg, solid-≥1 u/mg solid
Storage and Handling Store at -20 °C; Desiccated.
Unit Definition One unit causes the oxidation of one µ mole of acetaldehyde to acetic acid per minute at pH 8.0 and 25 °C in the presence of potassium ions and thiols.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.