Trichloroacetic Acid

Trichloroacetic Acid

Synonyms Trichloroethanoic Acid; TCA; Aceto-caustin; Acide trichloracetique; Acido tricloroacetico; Dow sodium inhibited; Konesta; Trichloressigsaeure; Varitox

CAS Number: 76-03-9 Molecular Formula: C2HCl3O2 Molecular Weight: 163.378 g/mol

Beilstein Registry Number: 970119 EC Number: 200-927-2 MDL Number: MFCD00004177

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SKU 02190521-CF
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Description

Product Description

Trichloroacetic Acid

Application Notes

Trichloroacetic acid is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation. It is also Used as a decalcifier and fixative in microscopy. A protocol for the precipitation of nucleic acids can be found in Molecular Cloning. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen. On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Decalcifier||Fixative||Determine protein concentration||Precipitation of Proteins

Specifications
SKU 02190521-CF
Alternate Names Trichloroethanoic Acid; TCA; Aceto-caustin; Acide trichloracetique; Acido tricloroacetico; Dow sodium inhibited; Konesta; Trichloressigsaeure; Varitox
Application Notes Trichloroacetic acid is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation. It is also Used as a decalcifier and fixative in microscopy. A protocol for the precipitation of nucleic acids can be found in Molecular Cloning. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit. In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen. On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.
Beilstein Registry Number 970119
Boiling Point 385 to 387° F at 760 mm Hg (NTP, 1992)
Certifications Protein precipitation reagent
Density 1.62 at 77° F (NTP, 1992)
EC Number 200-927-2
Flash Point greater than 230° F (NTP, 1992)
Format powder
Hazard Statements H314-H410
Applications Decalcifier||Fixative||Determine protein concentration||Precipitation of Proteins
MDL # MFCD00004177
Melting Point 135 to 136° F (NTP, 1992)
Molecular Formula C2HCl3O2
Molecular Weight 163.378 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
pH pH of 0.1 molar aq solution: 1.2
Physical Appearance Powder
Product Families Description Trichloroacetic acid
Product Overview Trichloroacetic Acid
Refractive Index n20/D 1.62(Lit.)
RTECS Number AJ7875000
Safety Symbol GHS05, GHS09
Solubility greater than or equal to 100 mg/mL at 72° F (NTP, 1992)
Storage and Handling Room Temperature; desiccate
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Density 5.6 (NTP, 1992) (Relative to Air)
Vapor Pressure 1 mm Hg at 123.8° F ; 5 mm Hg at 168.8° F (NTP, 1992)