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Chloramphenicol, PhytoPure™

Chloramphenicol, PhytoPure™

Synonyms D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol

CAS Number: 56-75-7 Molecular Formula: C11H12Cl2N2O5 Molecular Weight: 323.20

Beilstein Registry Number: 2225532 EC Number: 200-287-4 MDL Number: MFCD00078159

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SKU 02190321-CF
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Description

Product Description

A synthetic antibiotic first isolated from Streptomyces venezuelae. It is effective against gram-positive and gram-negative bacteria. It interferes with translation on the 50S ribosomal subunit at the peptidyl transferase step (elongation inhibition) and inhibits mitochondrial and chloroplast protein synthesis.

Application Notes

Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 02190321-CF
Application Notes Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Beilstein Registry Number 2225532
Biochemical Physiological Actions Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Boiling Point Sublimes
EC Number 200-287-4
Extinction Coefficient (278 nm) = 298 (water) (Lit.)
Format Crystalline off white powder
Hazard Statements H350
Melting Point 171
Molecular Formula C<sub>11</sub>H<sub>12</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>5</sub>
Molecular Weight 323.20
Optical Rotation (c=5 ethanol)+18 ° ± 5 °
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
pH NEUTRAL TO LITMUS
Physical Appearance Off-white Powder
Product Families Description Chloramphenicol
Product Overview Chloramphenicol
Purity >99%
RTECS Number AB6825000
Safety Symbol GHS08
Solubility Water Solubility2500 mg/L (at 25 °C)
Storage and Handling Room Temperature
Typical Working Concentration 5 -20 µg/mL
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 1.7X10-12 mm Hg at 25 deg C /Estimated/