Vinblastine Sulfate is used in cancer research.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Used in cancer research
|Application Notes||Vinblastine Sulfate is used in cancer research.|
|Beilstein Registry Number||3659812|
|Biochemical Physiological Actions||Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.|
|Applications||Used in cancer research|
|Melting Point||543 to 545° F (NTP, 1992)|
|Molecular Weight||909.061 g/mol|
|Physical Appearance||White Powder|
|Product Families Description||Vinblastine sulfate|
|Product Overview||Vinblastine Sulfate|
|Safety Symbol||GHS05, GHS07|
|Solubility||greater than or equal to 10 mg/mL at 76.1° F (NTP, 1992)|
|Storage and Handling||Store at +4 °C.|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|