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Retinoic Acid, All Trans Isomer

Retinoic Acid, All Trans Isomer

Synonyms Vitamin A acid; Tretinoin; ATRA; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8 -nonatetraenoic acid; Aberel; Airol; Aknoten; Cordes Vas; Dermairol; Retin-A; Vesnaroid

CAS Number: 302-79-4 Molecular Formula: C20H28O2 Molecular Weight: 300.442 g/mol

Beilstein Registry Number: 2057223 EC Number: 206-129-0 MDL Number: MFCD00001551

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SKU 02190269-CF
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Description

Product Description

Retinoic Acid, All Trans Isomer

Application Notes

Retinoic Acid has been used in various differentiation protocols, including B-cells, T cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Signaling molecule||Cancer Research

Specifications
SKU 02190269-CF
Application Notes Retinoic Acid has been used in various differentiation protocols, including B-cells, T cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy.
Beilstein Registry Number 2057223
Biochemical Physiological Actions All−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
EC Number 206-129-0
Hazard Statements H302
Applications Signaling molecule||Cancer Research
Loss on Drying ≤0.5%
Melting Point 354 to 360° F (NTP, 1992)
Molecular Formula C20H28O2
Molecular Weight 300.442 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Bright Yellow Powder
Product Families Description Retinoic acid
Product Overview Retinoic Acid, All Trans Isomer
RTECS Number VH6475000
Safety Symbol GHS07
Solubility less than 1 mg/mL at 77° F (NTP, 1992)
Storage and Handling Store at -0°C; desiccate; protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max (isopropanol + sulfuric acid)=353 ± 3 nm
Vapor Pressure 2.4X10-7 mm Hg @ 25 deg C /Estimated/