Dino

Naloxone Hydrochloride

Naloxone Hydrochloride

Synonyms Narcan; EN-1530; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5α- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;

CAS Number: 357-08-4 Molecular Formula: C19H21NO4 • HCl

Beilstein Registry Number: 6260807 EC Number: 206-611-0

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SKU 02190245-CF
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Description

Product Description

Naloxone Hydrochloride

Application Notes

The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Opiate antagonist

Specifications
SKU 02190245-CF
Application Notes The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.
Beilstein Registry Number 6260807
Biochemical Physiological Actions Naloxone has an extremely high affinity for μ-opioid receptors in the central nervous system. Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- and δ-opioid receptors.
EC Number 206-611-0
Format Crystalline powder
Hazard Statements H315-H319-H335
Applications Opiate antagonist
Molecular Formula C19H21NO4 • HCl
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Off-white Crystalline Powder
Product Families Description Naloxone hydrochloride
Product Overview Naloxone Hydrochloride
RTECS Number QD2275000
Safety Symbol GHS07
Storage and Handling Store at +4 °C; Store Desiccated.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.