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Indomethacin

Indomethacin

Synonyms Indometacin; 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid; 1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-1H-indole-3-acetic acid; 1-(p-Chlorobenzoyl)-5- methoxy-2-methyl-3- indolylacetic acid

CAS Number: 53-86-1 Molecular Formula: C19H16ClNO4 Molecular Weight: 357.79 g/mol

Beilstein Registry Number: 497341 EC Number: 200-186-5 MDL Number: MFCD00057095

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SKU 02190217-CF
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Description

Product Description

Indomethacin

Application Notes

Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotics||Antitumor Agent

Specifications
SKU 02190217-CF
Application Notes Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.
Beilstein Registry Number 497341
Biochemical Physiological Actions Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
EC Number 200-186-5
Extinction Coefficient EmM (230 nm) = 20.8 (in ethanol), EmM (260 nm) = 16.2 (in ethanol), EmM (319 nm) = 6.29 (in ethanol),(Lit.)
Format powder
Hazard Statements H300
Applications Antibiotics||Antitumor Agent
Melting Point 311 or 323.6° F (NTP, 1992)
Molecular Formula C19H16ClNO4
Molecular Weight 357.79 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, Respirator cartridge,Respirator filter
Physical Appearance Off-white Powder
pKa 4.5(Lit.)
Product Families Description Indomethacin
Product Overview Indomethacin
RTECS Number NL3500000
Safety Symbol GHS06
Solubility Water Solubility0.937 mg/L (at 25 °C)
Storage and Handling Store at Room Temperature (15-30 °C); protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 9.89X10-11 mm Hg at 25 deg C (est)