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Superoxide Dismutase N/H

Superoxide Dismutase N/H

Synonyms SOD; Superoxide: superoxide oxidoreductase

CAS Number: 9054-89-1 Molecular Weight: ~32;500 Daltons (Lit.)

EC Number: 232-943-0 MDL Number: MFCD00132404

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SKU 02190117-CF
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Description

Product Description

Superoxide dismutases are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen.Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.

Application Notes

Superoxide Dismutase plays a critical role in the defense of cells against the toxic effects of oxygen radicals.Superoxide dismutase from bovine erythrocytes has been used in a study to assess a kinetic model of radiation-induced inactivation of superoxide dismutase in nitrous oxide-saturated solutions. Superoxide dismutase from bovine erythrocytes has also been used in a study to investigate the possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Catalyst in dismutation of superoxide

Specifications
SKU 02190117-CF
Application Notes Superoxide Dismutase plays a critical role in the defense of cells against the toxic effects of oxygen radicals.Superoxide dismutase from bovine erythrocytes has been used in a study to assess a kinetic model of radiation-induced inactivation of superoxide dismutase in nitrous oxide-saturated solutions. Superoxide dismutase from bovine erythrocytes has also been used in a study to investigate the possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction.
Biochemical Physiological Actions Superoxide dismutase catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.
Concentration ≥0.900 mg protein/mg solid
EC Number 232-943-0
Extinction Coefficient 2.64 (1%/280) (Lit.)
Format Lyophilized salt-free powder
Isoelectric Point 4.95 (Lit.)
Applications Catalyst in dismutation of superoxide
Molecular Weight ~32;500 Daltons (Lit.)
Personal Protective Equipment Eyeshields, Gloves, Repirator Filter.
Physical Appearance Pale Blue Powder
Solubility Dissolves readily at 5mg/mL in 0.05M potassium phosphate/0.1mM EDTA pH 7.8, to give a clear slightly blue solution.
Source Bovine Erythrocytes
Specific Activity ≥3500 u/mg solid
Storage and Handling -20 °C; desiccate
Unit Definition That amount of enzyme causing a 50% inhibition in the rate of assay based on the method of McCord, J.M. and Fridovich, (1969), J. Biol. Chem., 1, 6049.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.