Neomycin Sulfate, USP

Neomycin Sulfate, USP

CAS Number: 1405-10-3 Molecular Formula: C23H46N6O13 • 3H2SO4 Molecular Weight: 908.9

EC Number: 215-773-1

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SKU 02180610-CF
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SKU 02180610-CF
Application Notes Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins.
Biochemical Physiological Actions Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
EC Number 215-773-1
Format powder
Grade USP
Hazard Statements H317-H334
Loss on Drying <8.0%
Molecular Formula C23H46N6O13 • 3H2SO4
Molecular Weight 908.9
Personal Protective Equipment dust mask, Eyeshields, Faceshields, Gloves
pH 5-7.5
Physical Appearance Powder
Safety Symbol GHS08
Solubility H2O: soluble50 mg/mL
Specific Activity ≥600 µg/mg
Storage and Handling Room Temperature; desiccate; protect from light
Typical Working Concentration It is recommended for use in cell culture applications at 50 mg/L.