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Dextran Sulfate Sodium Salt (400,000-600,000 M.Wt)

Dextran Sulfate Sodium Salt (400,000-600,000 M.Wt)

Synonyms Dextran sodium sulfate; DSS

CAS Number: 9011-18-1 Molecular Weight: 165.192 g/mol

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SKU 02160111-CF
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Description

Product Description

Dextran Sulfate Sodium Salt (400,000-600,000 M.Wt)

Application Notes

Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.DSS increases the rate of nucleic acids hybridization. In the presence of 10% dextran sulfate sodium salt (DSS) the rate of re-annealing of DNA in solution was increased by about 10 times. This observation was later extended to the hybridization of single or double-stranded probes to DNA or RNA immobilized on filter paper. The addition of 10% dextran sulfate may increase the rate of hybridization of randomly cleaved double-stranded DNA probes to immobilized nucleic acids by as much as 100 times. Dextran sulfate sodium salt may be used as an accelerant to decrease the time required for probe annealing. DSS may be included in the hybridization buffer when the rate of hybridization is a limiting factor in detecting rare sequences or it may be included in the hybridization buffer when a limited amount of probe is available. DSS also functions as an accelerant by excluding the nucleic acid from the volume of solution occupied by the polymer, thereby, increasing the effective probe concentration.Antiviral – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Hybridization||Immunology||Antiviral||Antipemic||Molecular Biology

Specifications
SKU 02160111-CF
Application Notes Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.DSS increases the rate of nucleic acids hybridization. In the presence of 10% dextran sulfate sodium salt (DSS) the rate of re-annealing of DNA in solution was increased by about 10 times. This observation was later extended to the hybridization of single or double-stranded probes to DNA or RNA immobilized on filter paper. The addition of 10% dextran sulfate may increase the rate of hybridization of randomly cleaved double-stranded DNA probes to immobilized nucleic acids by as much as 100 times. Dextran sulfate sodium salt may be used as an accelerant to decrease the time required for probe annealing. DSS may be included in the hybridization buffer when the rate of hybridization is a limiting factor in detecting rare sequences or it may be included in the hybridization buffer when a limited amount of probe is available. DSS also functions as an accelerant by excluding the nucleic acid from the volume of solution occupied by the polymer, thereby, increasing the effective probe concentration.Antiviral – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells.
Boiling Point 310 °C
Applications Hybridization||Immunology||Antiviral||Antipemic||Molecular Biology
Loss on Drying <10%
Melting Point 92 °C
Molecular Weight 165.192 g/mol
Optical Rotation +75 ° to +105 ° (c=1, water)
Personal Protective Equipment Eyeshields, Gloves,respirator filter
Physical Appearance White Powder
Product Families Description Dextran sulfate sodium salt
Product Overview Dextran Sulfate Sodium Salt (400,000-600,000 M.Wt)
RTECS Number HH9290000
Solubility >24.8 [ug/mL]
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 2.6X10-4 mm Hg at 25 deg C /Estimated/