Dextran Sulfate Sodium Salt (DSS) - Colitis Grade (36,000-50,000 MW)

Dextran Sulfate Sodium Salt (DSS) - Colitis Grade (36,000-50,000 MW)

Synonyms Dextran sodium sulfate; DSS

CAS Number: 9011-18-1 Molecular Weight: 165.192 g/mol

MDL Number: MFCD00081551

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SKU 02160110-CF
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Description

Product Description

Dextran Sulfate Sodium Salt (36,000-50,000 M.Wt.) Colitis Grade

Application Notes

Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sodium sulfate (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD. Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. Their study concluded that the DSS from MP Biomedicals induced a severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the following advantages: • Highest sulfur content – 19%• Highest chirality - +104° of specific rotation• Lowest pH – 6.2 at 1% solution

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals

Key Applications

Colitis||Antilipemic

Specifications
SKU 02160110-CF
Alternate Names Dextran sodium sulfate; DSS
Application Notes Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sodium sulfate (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD. Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. Their study concluded that the DSS from MP Biomedicals induced a severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the following advantages: • Highest sulfur content – 19%• Highest chirality - +104° of specific rotation• Lowest pH – 6.2 at 1% solution
Boiling Point 310 °C
Grade Colitis grade
Applications Colitis||Antilipemic
MDL # MFCD00081551
Melting Point 92 °C
Moisture Content <10%
Molecular Weight 165.192 g/mol
Optical Rotation +75 ° to 105 °
Pack Size No
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White powder
Product Families Description Dextran sulfate sodium salt
Product Overview Dextran Sulfate Sodium Salt (36,000-50,000 M.Wt.) Colitis Grade
Residue on Ignition <50%
RTECS Number HH9290000
Solubility >24.8 [ug/mL]
Storage and Handling Store at Room Temperature (15-30 °C)
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals
Vapor Pressure 2.6X10-4 mm Hg at 25 deg C /Estimated/