β-Nicotinamide Adenine Dinucleotide Reduced Disodium Salt

β-Nicotinamide Adenine Dinucleotide Reduced Disodium Salt

Synonyms β-NADH, 2Na; Reduced DPN; Cozymase, reduced form; Dihydrophosphopyridine nucleotide; Dihydronicotinamide adenine dinucleotide; Diphosphopyridine nucleotide, reduced form; β-DPNH; DPNH; NADH

CAS Number: 24292-60-2 Molecular Formula: C21H27N7O14P2Na2 Molecular Weight: 787.372 g/mol

EC Number: 210-123-3 MDL Number: MFCD03791273

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SKU 02160050-CF
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Description

Product Description

β-Nicotinamide Adenine Dinucleotide Reduced Disodium Salt

Application Notes

β-Nicotinamide adenine dinucleotide and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Oxidation reduction reactions

Specifications
SKU 02160050-CF
Alternate Names β-NADH, 2Na; Reduced DPN; Cozymase, reduced form; Dihydrophosphopyridine nucleotide; Dihydronicotinamide adenine dinucleotide; Diphosphopyridine nucleotide, reduced form; β-DPNH; DPNH; NADH
Application Notes β-Nicotinamide adenine dinucleotide and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases). As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Biochemical Physiological Actions NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
Certifications Meets or exceeds NRC specifications
EC Number 210-123-3
Extinction Coefficient EmM= 6.22 (340 nm) and 14.4 (259 nm, pH 9.5)(Lit.)
Format powder
Hazard Statements H315-H319-H335
Applications Oxidation reduction reactions
MDL # MFCD03791273
Molecular Formula C21H27N7O14P2Na2
Molecular Weight 787.372 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description β-Nicotinamide-adenine dinucleotide reduced
Product Overview β-Nicotinamide Adenine Dinucleotide Reduced Disodium Salt
Purity ≥98%
Safety Symbol GHS07
Storage and Handling Store at -0 °C. Store desiccated. Protect from light. Store under nitrogen.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max (water): 258 - 260 nm