Anisomycin

Anisomycin

Synonyms 2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin

CAS Number: 22862-76-6 Molecular Formula: C14H19NO4 Molecular Weight: 265.309 g/mol

Beilstein Registry Number: 20705 EC Number: 245-269-7 MDL Number: MFCD00077650

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SKU 02159881-CF
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Description

Product Description

Anisomycin

Application Notes

Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibits protein synthesis|| Activates a restricted subset of kinases||Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

Specifications
SKU 02159881-CF
Alternate Names 2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
Application Notes Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
Beilstein Registry Number 20705
Biochemical Physiological Actions Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
EC Number 245-269-7
Format powder
Hazard Statements H301
Applications Inhibits protein synthesis|| Activates a restricted subset of kinases||Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
MDL # MFCD00077650
Molecular Formula C14H19NO4
Molecular Weight 265.309 g/mol
Optical Rotation [α]D23 = −30 ° (methanol) (Lit.)
Personal Protective Equipment Eyeshields, Faceshields, Gloves, respirator cartridges
Physical Appearance White Powder
Product Families Description Anisomycin
Product Overview Anisomycin
Purity ≥97%
RTECS Number BZ9800000
Safety Symbol GHS06
Source Streptomyces griseolus
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.