Rosmarinic Acid

Rosmarinic Acid

Synonyms (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester

CAS Number: 20283-92-5 Molecular Formula: C18H16O8 Molecular Weight: 360.318 g/mol

Beilstein Registry Number: 2227587 MDL Number: MFCD00017740

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SKU 02159792-CF
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Description

Product Description

Rosmarinic Acid

Application Notes

Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be a activator of GPR35.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02159792-CF
Alternate Names (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester
Application Notes Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be a activator of GPR35.
Beilstein Registry Number 2227587
Biochemical Physiological Actions Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and cancer chemoprevention.
Density 1.547 g/cu cm
Format powder
Hazard Statements H301-H400
MDL # MFCD00017740
Melting Point 171-175 deg C
Molecular Formula C18H16O8
Molecular Weight 360.318 g/mol
Physical Appearance Beige Powder
Product Families Description Rosmarinic acid
Product Overview Rosmarinic Acid
RTECS Number GD8990000
Safety Symbol GHS06, GHS09
Solubility Soluble in <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>, <a class="pubchem-internal-link CID-679" href="https://pubchem.ncbi.nlm.nih.gov/compound/DMSO">DMSO</a> or <a class="pubchem-internal-link CID-6228" href="https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl-formamide">dimethyl formamide</a> to approximately 25 mg/mL
Storage and Handling Store at Room Temperature (15-30 °C). Protect from light.
Typical Working Concentration inhibits lipid peroxidation of rat liver microsomes b 90% at a concentration of 25 µg/ml.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 1.1X10-13 mm Hg at 25 deg C (est)