Clozapine

Clozapine

Synonyms HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801

CAS Number: 5786-21-0 Molecular Formula: C18H19N4Cl Molecular Weight: 326.828 g/mol

EC Number: 227-313-7 MDL Number: MFCD00153785

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SKU 02159760-CF
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Description

Product Description

Clozapine

Application Notes

Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Blocking of dopamine receptor

Specifications
SKU 02159760-CF
Alternate Names HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
Application Notes Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.
Biochemical Physiological Actions A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
EC Number 227-313-7
Extinction Coefficient Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.)
Format powder
Gene ID Human(148), Mouse(11549), Rat(29412)
Gene Symbol and Aliases a 1a, ADRA1A, ADRA1C, ADRA1L1, ADRA1α, Adrenergic Receptor alpha1a, Alpha 1a adrenergic receptor, Alpha1a adrenoceptor, Alpha1a adrenoreceptor, ALPHA1AAR, BOS 9098, MGC130524
Hazard Statements H301-H341-H361
Applications Blocking of dopamine receptor
MDL # MFCD00153785
Melting Point 183-184 °C
Molecular Formula C18H19N4Cl
Molecular Weight 326.828 g/mol
Physical Appearance Yellow Powder
Product Families Description Clozapine
Product Overview Clozapine
RTECS Number HP1750000
Safety Symbol GHS06, GHS08
Solubility Water Solubility11.8 mg/L
Storage and Handling Store at Room Temperature (15-30 °C). Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 1.12X10-8 mm Hg at 25 deg C (est)