Camptothecin

Camptothecin

Synonyms Camptothecine; (S)-(+)-Camptothecin

CAS Number: 2114454 Molecular Formula: C20H16N2O4

Beilstein Registry Number: 631069 MDL Number: MFCD00081076

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SKU 02159732-CF
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Description

Product Description

Camptothecin

Application Notes

Camptothecin used to study transbilayer phospholipid movements by inducing apoptosis in EBV transformed B lymphocytes from ABCA1-Deficient Cells. Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Binds to and stabilizes the topoisomerase-DNA covalent complex

Specifications
SKU 02159732-CF
Alternate Names Camptothecine; (S)-(+)-Camptothecin
Application Notes Camptothecin used to study transbilayer phospholipid movements by inducing apoptosis in EBV transformed B lymphocytes from ABCA1-Deficient Cells. Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
Beilstein Registry Number 631069
Biochemical Physiological Actions (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Extinction Coefficient EmM = 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm) (Lit.)
Format solid
Hazard Statements H302
Applications Binds to and stabilizes the topoisomerase-DNA covalent complex
MDL # MFCD00081076
Molecular Formula C20H16N2O4
Optical Rotation -139.5 ° (10 mg/mL, pyridine, 25 °C) (Lit.)
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridges
Physical Appearance Pale Yellow Solid
Product Families Description Camptothecin
Product Overview Camptothecin
Purity ≥97%
Refractive Index n20D 1.75 (Lit.)
RTECS Number UQ0492000
Safety Symbol GHS07
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.