Dino

Ionomycin

Ionomycin

CAS Number: 56092-81-0 Molecular Weight: 709.018 g/mol

Beilstein Registry Number: 3642126 MDL Number: MFCD06798385

Packaging size: 1 mg

SKU 0215961101
Price:
$134.25
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Description

Product Description

Ionomycin

Application Notes

Ionomycin is a useful tool for increasing intracellular Ca2+ concentration . It is also used to equilibrate intracellular and extracellular calcium ion levels for in situ calibrations of fluorescent indicators. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Studies of Ca2+ transport||Equilibrate intracellular and extracellular calcium ion levels||Selective calcium ionophore

Specifications
SKU 0215961101
Application Notes Ionomycin is a useful tool for increasing intracellular Ca2+ concentration . It is also used to equilibrate intracellular and extracellular calcium ion levels for in situ calibrations of fluorescent indicators. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Beilstein Registry Number 3642126
Biochemical Physiological Actions Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination and inhibits adrenal bovine TREK-1 channels.
Format Gel
Hazard Statements H302
Applications Studies of Ca2+ transport||Equilibrate intracellular and extracellular calcium ion levels||Selective calcium ionophore
Molecular Weight 709.018 g/mol
Pack Size 1 mg
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Clear Gel
Product Families Description Ionomycin
Product Overview Ionomycin
Purity ≥90%
RTECS Number NO0600000
Safety Symbol GHS07
Source Streptomyces conglobatus
Storage and Handling Store at -20 °C; protect from light.
Typical Working Concentration Ionomycin is used at concentration of 3nM and 2-4µM (whole cells).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.