Bafilomycin A1

Bafilomycin A1

CAS Number: 88899-55-2 Molecular Weight: 622.84 g/mol

Beilstein Registry Number: 4730700 MDL Number: MFCD06795130

Packaging size: 100 μg

SKU 0215955580
Price:
$125.50
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Description

Product Description

Bafilomycin A1

Application Notes

Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Active against gram-positive bacteria and fungi||ATPase inhibitor

Specifications
SKU 0215955580
Application Notes Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation.
Beilstein Registry Number 4730700
Biochemical Physiological Actions A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
Format Clear film
Hazard Statements H315-H319-H335
Applications Active against gram-positive bacteria and fungi||ATPase inhibitor
MDL # MFCD06795130
Molecular Weight 622.84 g/mol
Pack Size 100 μg
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Clear Film
Product Families Description Bafilomycin A1
Product Overview Bafilomycin A1
Purity ~90%
Safety Symbol GHS07
Source Streptomyces griseus
Storage and Handling Store at -20 °C; protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.