Dino

Rapamycin

Rapamycin

Synonyms NSC226080; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; AY 22989; Sirolimus; Rapamune

CAS Number: 53123-88-9 Molecular Formula: C51H79NO13 Molecular Weight: 914.187 g/mol

MDL Number: MFCD00867594

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SKU 02159346-CF
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Description

Product Description

Rapamycin

Application Notes

Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Induces autophagy in yeast and mammalian cell lines.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotic||Anticancer agent||Immunosuppressant

Specifications
SKU 02159346-CF
Application Notes Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. Induces autophagy in yeast and mammalian cell lines.
Biochemical Physiological Actions Rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Extinction Coefficient E1 %, 1 cm (maximum wavelength, 95% ethanol) is: 417 (267 nm); 541 (277 nm); 416 (288 nm)(Lit.)
Format powder
Hazard Statements H317
Applications Antibiotic||Anticancer agent||Immunosuppressant
Melting Point 183-185 deg C
Molecular Formula C51H79NO13
Molecular Weight 914.187 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White powder
Product Families Description Rapamycin
Product Overview Rapamycin
Purity ≥98%
RTECS Number VE6250000
Solubility Sol in ether, <a class="pubchem-internal-link CID-6212" href="https://pubchem.ncbi.nlm.nih.gov/compound/chloroform">chloroform</a>, <a class="pubchem-internal-link CID-180" href="https://pubchem.ncbi.nlm.nih.gov/compound/acetone">acetone</a>, <a class="pubchem-internal-link CID-887" href="https://pubchem.ncbi.nlm.nih.gov/compound/methanol">methanol</a>, and <a class="pubchem-internal-link CID-6228" href="https://pubchem.ncbi.nlm.nih.gov/compound/DMF">DMF</a>; very sparingly sol in <a class="pubchem-internal-link CID-8058" href="https://pubchem.ncbi.nlm.nih.gov/compound/hexane">hexane</a> and petr ether.
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.