Ketoconazole

Ketoconazole

Synonyms cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine

CAS Number: 65277-42-1 Molecular Formula: C26H28N4O4Cl2 Molecular Weight: 531.434 g/mol

EC Number: 265-667-4 MDL Number: MFCD00058579

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SKU 02159158-CF
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Description

Product Description

Ketoconazole

Application Notes

Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotics||Antifungal||Enzyme

Specifications
SKU 02159158-CF
Alternate Names cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
Application Notes Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.
Biochemical Physiological Actions Ketoconazole as an Antifungal agent, interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
EC Number 265-667-4
Format powder
Hazard Statements H301-H360F-H373-H410
Applications Antibiotics||Antifungal||Enzyme
MDL # MFCD00058579
Melting Point 146
Molecular Formula C26H28N4O4Cl2
Molecular Weight 531.434 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Respirator cartridges
Physical Appearance White Powder
Product Families Description Ketoconazole
Product Overview Ketoconazole
Purity ≥98%
RTECS Number TK7912300
Safety Symbol GHS06, GHS08, GHS09
Solubility <h5 class="minor-section-title">Water Solubility</h5>0.0866 mg/L
Storage and Handling Room Temperature
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 6.41X10-14 mm Hg at 25 deg C (est)