Doxorubicin Hydrochloride

Doxorubicin Hydrochloride

Synonyms Adriamycin; 14-Hydroxydaunomycin; HCl; DOX; Hydroxydaunorubicin hydrochloride; 14-Hydroxydaunomycin hydrochloride; 10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl) hydrochloride; Doxorubicin

CAS Number: 25316-40-9 Molecular Formula: C27H29NO11·HCl Molecular Weight: 579.983 g/mol

Beilstein Registry Number: 4229251 EC Number: 246-818-3 MDL Number: MFCD00077757

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SKU 02159101-CF
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Description

Product Description

Doxorubicin Hydrochloride

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Chemotherapeutic agent

Specifications
SKU 02159101-CF
Alternate Names Adriamycin; 14-Hydroxydaunomycin; HCl; DOX; Hydroxydaunorubicin hydrochloride; 14-Hydroxydaunomycin hydrochloride; 10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl) hydrochloride; Doxorubicin
Beilstein Registry Number 4229251
Biochemical Physiological Actions Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis. Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
EC Number 246-818-3
Format powder
Hazard Statements H302-H350
Applications Chemotherapeutic agent
MDL # MFCD00077757
Melting Point 399 to 401° F (Decomposes) (NTP, 1992)
Molecular Formula C27H29NO11·HCl
Molecular Weight 579.983 g/mol
Personal Protective Equipment Eyeshields, Full-face respirator, Gloves, Multi-purpose combination respirator cartridge, Respirator filter
Physical Appearance Reddish Orange Powder
Product Families Description Doxorubicin hydrochloride
Product Overview Doxorubicin Hydrochloride
Purity ≥95%
RTECS Number QI9295900
Safety Symbol GHS07, GHS08
Solubility Soluble (NTP, 1992)
Storage and Handling Room Temperature; desiccate; protect from light
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 2.5X10-23 at 25 deg C (est)