Compound 48/80 used to induce degranulation of GnRH-like immunoreactivity of mast cells in the brain and mesentery and for elucidating the mechanism by which anti-allergic medications suppress conjunctivitis.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Potent histamine releasing agent
|Application Notes||Compound 48/80 used to induce degranulation of GnRH-like immunoreactivity of mast cells in the brain and mesentery and for elucidating the mechanism by which anti-allergic medications suppress conjunctivitis.|
|Biochemical Physiological Actions||Potent histamine releasing agent, primarily from mast cells, with a subsequent depletion of tissue histamine. It is the action of mast cell mediators on the cardiovascular system that leads to circulatory collapse. The toxicity is due to more than histamine release. It is a potent inhibitor of phospholipase C. Activates G proteins by a mechanism analogous to that of mastorparan. Inhibits calmodulin and human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.|
|Applications||Potent histamine releasing agent|
|Molecular Weight||519.73 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, respirator cartridges|
|Physical Appearance||White Powder|
|Product Families Description||Compound 48/80|
|Product Overview||Compound 48/80|
|Storage and Handling||-20 °C. Store Desiccated|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|