Tamoxifen Citrate Salt

Tamoxifen Citrate Salt

Synonyms [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; trans-Tamoxifen; Z-Tamoxifen; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine; trans-1-(p-b- Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; Kessar; Tamofen; Terimon; ICI 46474; Z-Tamoxifen Citrate

CAS Number: 54965-24-1 Molecular Formula: C26H29NO·C6H8O7 Molecular Weight: 563.647 g/mol

EC Number: 259-415-2 MDL Number: MFCD00058321

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SKU 02156739-CF
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Description

Product Description

Tamoxifen Citrate Salt

Application Notes

Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7.5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats. Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Protein kinase C inhibitor||Induces apoptosis||Mixed estrogen agonists/antagonists

Specifications
SKU 02156739-CF
Alternate Names [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; trans-Tamoxifen; Z-Tamoxifen; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine; trans-1-(p-b- Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; Kessar; Tamofen; Terimon; ICI 46474; Z-Tamoxifen Citrate
Application Notes Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7.5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats. Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.
Biochemical Physiological Actions Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
EC Number 259-415-2
Format powder
Hazard Statements H302-H350-H360
Applications Protein kinase C inhibitor||Induces apoptosis||Mixed estrogen agonists/antagonists
MDL # MFCD00058321
Molecular Formula C26H29NO·C6H8O7
Molecular Weight 563.647 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator cartridge respirator filter
Physical Appearance White Powder
pKa approximately 8.854; approximately 6.9 (in Triton® X-100)(Lit.)
Product Families Description Tamoxifen
Product Overview Tamoxifen Citrate Salt
RTECS Number KH2387000
Safety Symbol GHS07, GHS08
Storage and Handling Store at +4 °C. Store desiccated. Protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.