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Sulfamethazine Sodium Salt

Sulfamethazine Sodium Salt

Synonyms 4-Amino-N-[4,6-dimethyl-2-pyrimidinyl]benzenesulfonamide

CAS Number: 1981-58-4 Molecular Formula: C12H13N4O2SNa Molecular Weight: 300.312 g/mol

EC Number: 217-840-0 MDL Number: MFCD00068333

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SKU 02156709-CF
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Description

Product Description

Sulfamethazine Sodium Salt

Application Notes

Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotic

Specifications
SKU 02156709-CF
Application Notes Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine.
Biochemical Physiological Actions Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Density 1.4655 g/cu cm
EC Number 217-840-0
Format powder
Hazard Statements H302
Applications Antibiotic
Melting Point 176 deg C (also reported as mp 178-179 deg C; mp 198-199 deg C; mp 205-207 deg C)
Molecular Formula C12H13N4O2SNa
Molecular Weight 300.312 g/mol
Physical Appearance White Powder
Product Families Description Sulfamethazine
Product Overview Sulfamethazine Sodium Salt
RTECS Number WO9300000
Safety Symbol GHS07
Solubility In <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>, 1.50X10+3 mg/L at 29 deg C and 1.92X10+3 mg/L at 37 deg C; solubility increases with increasing pH
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 6.82X10-9 mm Hg at 25 deg C (est)