Dino

13-Cis-Retinoic Acid

13-Cis-Retinoic Acid

Synonyms Isotretinoin

CAS Number: 4759-48-2 Molecular Formula: C20H28O2 Molecular Weight: 300.442 g/mol

EC Number: 225-296-0 MDL Number: MFCD00079542

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SKU 02156518-CF
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Description

Product Description

13-Cis-Retinoic Acid

Application Notes

13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Anti-inflammatory||Anti-tumor

Specifications
SKU 02156518-CF
Application Notes 13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
Biochemical Physiological Actions The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.
EC Number 225-296-0
Format powder
Hazard Statements H315-H319-H335-H360
Applications Anti-inflammatory||Anti-tumor
Melting Point 372 to 374° F (NTP, 1992)
Molecular Formula C20H28O2
Molecular Weight 300.442 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Physical Appearance Orange Powder
Product Families Description 13-cis-Retinoic acid
Product Overview 13-Cis-Retinoic Acid
RTECS Number VH6440000
Safety Symbol GHS07, GHS08
Solubility less than 1 mg/mL at 72° F (NTP, 1992)
Storage and Handling Store at -20 °C. Store Under Nitrogen. Protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max (ethanol): 354 ± 3 nm
Vapor Pressure 1.0X10-7 mm Hg @ 25 deg C /Estimated/