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Novobiocin Sodium Salt

Novobiocin Sodium Salt

Synonyms Albamycin; Cathomycin sodium

CAS Number: 1476-53-5 Molecular Formula: C31H35N2O11Na Molecular Weight: 634.614 g/mol

EC Number: 216-023-6

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SKU 02155957-CF
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Description

Product Description

Novobiocin Sodium Salt

Application Notes

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02155957-CF
Application Notes For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.
Biochemical Physiological Actions Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.Antimicrobial spectrum: Gram-positive bacterial.Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB 2. It is also a Hsp90 inhibitor 3. Antimicrobial spectrum: Gram-positive bacterial.
EC Number 216-023-6
Extinction Coefficient E1%= 600 (0.1 M NAOH)
Format powder
Molecular Formula C31H35N2O11Na
Molecular Weight 634.614 g/mol
Optical Rotation -38.0°(2.5 g/100 ml ethanol at24°C for the free acid)
Physical Appearance White powder
Potency ~900 µg/mg
Product Families Description Novobiocin
Product Overview Novobiocin Sodium Salt
Residue on Ignition ≤12%
RTECS Number RD5425000
Storage and Handling Store at 2-8C.
Typical Working Concentration The minimum inhibitory concentration (MIC) toward gram-positive bacteria is 0.1 to 4 µg/ml
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λmax: 307 nm