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Niclosamide

Niclosamide

Synonyms 2´,5-Dichloro-4-nitrosalicylanilide

CAS Number: 50-65-7 Molecular Formula: C13H8Cl2N2O4 Molecular Weight: 327.117 g/mol

Beilstein Registry Number: 2820605 EC Number: 200-056-8 MDL Number: MFCD00057597

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SKU 02155827-CF
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Description

Product Description

Niclosamide

Application Notes

Niclosamide is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotic||Inhibit the transcription and DNA binding of NF-κB in AML cells

Specifications
SKU 02155827-CF
Application Notes Niclosamide is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis.
Beilstein Registry Number 2820605
Biochemical Physiological Actions Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.
EC Number 200-056-8
Format powder
Hazard Statements H400
Applications Antibiotic||Inhibit the transcription and DNA binding of NF-κB in AML cells
Loss on Drying ≤0.5%
Melting Point 230 °C
Molecular Formula C13H8Cl2N2O4
Molecular Weight 327.117 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Greenish-Yellow Powder
Product Families Description Niclosamide
Product Overview Niclosamide
Purity ≥98%
RTECS Number VN8400000
Safety Symbol GHS09
Solubility Water Solubility1.6 mg/L (at 20 °C)
Storage and Handling Store at Room Temperature (15-30 °C).
Sulphated Ash ≤0.1%
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure <9.87X10-9 mm Hg at 20 deg C