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Cefotaxime Sodium Salt, PhytoPure™

Cefotaxime Sodium Salt, PhytoPure™

Synonyms Cefotaxime sodium; (6R-(6-a,7-b(Z)))-3-((Acetyloxy) methyl)-7- (((2-amino-4-thiazolyl) (methoxyimio) acetyl) amino)-8- oxo-5-thia-1- azabicyclo (4,2,0) oct-2-ene-2-carboxylic acid, sodium salt

CAS Number: 64485-93-4 Molecular Formula: C16H16N5O7S2Na Molecular Weight: 477.40

Beilstein Registry Number: 5711411 EC Number: 264-915-9 MDL Number: MFCD00079073

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SKU 02154947-CF
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Description

Product Description

A cephalosporin antibiotic effective against gram-positive and gram-negative bacteria. It interferes with cell wall formation by inhibiting cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls. Useful in plant cell culture because it doesn't affect the plasmids of developed vascular plants.

Application Notes

Cefotaxime is used for infections of the respiratory tract, skin, bones, joints, urogenital system, meninges, and bloodstream. It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Cell wall inhibitor

Specifications
SKU 02154947-CF
Application Notes Cefotaxime is used for infections of the respiratory tract, skin, bones, joints, urogenital system, meninges, and bloodstream. It generally has good coverage against most Gram-negative bacteria, with the notable exception of Pseudomonas. It is also effective against most Gram-positive cocci except for Enterococcus. It is active against penicillin-resistant strains of Streptococcus pneumoniae. It has modest activity against the anaerobic Bacteroides fragilis. In meningitis, cefotaxime crosses the blood–brain barrier better than cefuroxime.
Beilstein Registry Number 5711411
Biochemical Physiological Actions Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
EC Number 264-915-9
Hazard Statements H317-H334
Applications Cell wall inhibitor
Molecular Formula C<sub>16</sub>H<sub>16</sub>N<sub>5</sub>O<sub>7</sub>S<sub>2</sub>Na
Molecular Weight 477.40
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
Physical Appearance Off White Powder
Product Families Description Cefotaxime
Product Overview Cefotaxime Sodium Salt
Purity ≥95%
RTECS Number XI0250000
Safety Symbol GHS08
Solubility 68.2 [ug/mL]
Storage and Handling Store at +4 °C; protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.