Bumetanide

Bumetanide

Synonyms Ro 10-6338; 3-(aminosulfonyl)-5-(butylamino)- 4-phenoxybenzoic acid; 3-(butylamino)-4-phenoxy- 5-sulfamoylbenzoic acid

CAS Number: 28395-03-1 Molecular Formula: C17H20N2O5S Molecular Weight: 364.416 g/mol

EC Number: 249-004-6 MDL Number: MFCD00078949

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SKU 02154263-CF
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Description

Product Description

Bumetanide

Application Notes

Bumetanide has been used to probe the role of prostaglandin E2 in the regulation of chloride secretion across porcine endometrial epithelial cells. A study of the effects of bumetanide application and subsequent sodium potassium chloride cotransporter (NKCC1) inhibition in cultured liver cells has indicated increased α1-smooth muscle actin expression in 2-day-cultured hepatic stellate cells. An investigation of lactacidosis treatment of suspended G6 glial cells with bumetanide included at 0.1 mM has shown diminished cell swelling due to lactacidosis.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02154263-CF
Alternate Names Ro 10-6338; 3-(aminosulfonyl)-5-(butylamino)- 4-phenoxybenzoic acid; 3-(butylamino)-4-phenoxy- 5-sulfamoylbenzoic acid
Application Notes Bumetanide has been used to probe the role of prostaglandin E2 in the regulation of chloride secretion across porcine endometrial epithelial cells. A study of the effects of bumetanide application and subsequent sodium potassium chloride cotransporter (NKCC1) inhibition in cultured liver cells has indicated increased α1-smooth muscle actin expression in 2-day-cultured hepatic stellate cells. An investigation of lactacidosis treatment of suspended G6 glial cells with bumetanide included at 0.1 mM has shown diminished cell swelling due to lactacidosis.
Biochemical Physiological Actions Inhibitor of Na+/K+/Cl- cotransporter.
EC Number 249-004-6
Format powder
MDL # MFCD00078949
Melting Point 230-231
Molecular Formula C17H20N2O5S
Molecular Weight 364.416 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
Product Families Description Bumetanide
Product Overview Bumetanide
Purity ≥99%
RTECS Number DG4910000
Solubility >54.7 [ug/mL]
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.