Thrombin

Thrombin

Synonyms Factor IIa

CAS Number: 2594047

EC Number: 232-648-7 MDL Number: MFCD00166053

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SKU 02154163-CF
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Description

Product Description

Thrombin

Application Notes

α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Research tool||Medicine||Surgery||Food Industry

Specifications
SKU 02154163-CF
Alternate Names Factor IIa
Application Notes α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.
Biochemical Physiological Actions Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
EC Number 232-648-7
Foreign Activity Plasminogen and plasmin not detected.
Grade High purity grade
Hazard Statements H315-H319-H334-H335
Applications Research tool||Medicine||Surgery||Food Industry
MDL # MFCD00166053
Physical Appearance White Powder
Product Families Description Thrombin
Product Overview Thrombin
RTECS Number XO8950000
Safety Symbol GHS07, GHS08
Source Bovine
Specific Activity ≥1500 NIH u/mg protein
Storage and Handling Store at -20°C
Unit Definition The unit defined by the U.S. standard and is approximately equal to the stated unitage. A U.S. unit is defined as the amount required to clot 1 mL of standardized fibrinogen solution in 15 seconds. Approximately 2 U.S. units are required to clot 1 ml of oxalated human plasma in the same period of time. U.S units = NIH units.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.