β2-Microglobulin

β2-Microglobulin

Synonyms β2-Microglobulin; β2-M

CAS Number: Not applicable

MDL Number: MFCD00130615

Packaging size: 500 µg

SKU 02153903.5
Price:
$410.80
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Description

Product Description

β2-Microglobulin

Application Notes

To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Stability of the MHC antigens

Specifications
SKU 02153903.5
Alternate Names β2-Microglobulin; β2-M
Application Notes To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.
Biochemical Physiological Actions A transient complex of MHC heavy chain and β2-Microglobulin is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-Microglobulin complex to the cell surface. Absence of binding leads to degradation in the proteasome.
Certifications Tested and found negative for HIV 1&2, Hepatitis B, and Hepatitis C.
Format solid
Formulation Lyophilized from 0.02 M NH4(HCO3)
Applications Stability of the MHC antigens
MDL # MFCD00130615
Pack Size 500 µg
Physical Appearance White Solid
Product Families Description β-2-Microglobulin
Product Overview β2-Microglobulin
Purity 30 - 60 %
Source Human Urine
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.