(6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride

(6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride

Synonyms (6R)-BH4-Amino-6-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride; BH4; (6R)-BH4; (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin; Dapropterin

CAS Number: 17528-72-2 Molecular Formula: C9H15N5O3·2HCl Molecular Weight: 241.251 g/mol

MDL Number: MFCD00891665

Configure Your Product:

SKU 02153622-CF
Price:
$201.60
In Stock
Request a quote
Description

Product Description

(6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride

Application Notes

(6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Cofactor

Specifications
SKU 02153622-CF
Alternate Names (6R)-BH4-Amino-6-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride; BH4; (6R)-BH4; (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin; Dapropterin
Application Notes (6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.
Biochemical Physiological Actions Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.
Extinction Coefficient EM(216 nm)=15,400 (0.1 N HCl); (264 nm) = 13,750 (0.1 N HCl)(Lit.)
Format powder
Hazard Statements H302
Applications Cofactor
MDL # MFCD00891665
Melting Point 250 - 255 °C (hydrochloride salt)
Molecular Formula C9H15N5O3·2HCl
Molecular Weight 241.251 g/mol
Optical Rotation [α]D = -6.6° to –7.6° (C = 1 in 0.1 N HCl)(Lit.)
Physical Appearance White Powder
Product Families Description (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
Product Overview (6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride
RTECS Number UO3516000
Safety Symbol GHS07
Storage and Handling Store at -20 °C. Store Desiccated.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.