Hydroxypropyl Β-Cyclodextrin

Hydroxypropyl Β-Cyclodextrin

Synonyms HBC; 2-Hydroxypropylether-b-cyclodextrin; (2-Hydroxypropyl)-ß-cyclodextrin

CAS Number: 94035-02-6 Molecular Formula: (C6H9O5)× • (C3H7O)× Molecular Weight: 1375.371 g/mol

EC Number: 420-920-1

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SKU 02153540-CF
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$32.70
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Description

Product Description

Hydroxypropyl Β-Cyclodextrin

Application Notes

2-Hydroxypropyl-beta-Cyclodextrin are non-toxic solubilizers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states. Solutions of many such complexes may be lyophilized to produce freely soluble powders which may be compressed into tablets. Bio-effects are only slightly affected by cyclodextrin complexation. Cells in serum supplemented medium can be grown in up to 1-2%. In serum-free medium, concentrations of 0.5-1% are acceptable. Hydroxypropyl-b-cyclodextrin has been found to be non-toxic in mice and rabbits. 2-hydroxypropyl-g-cyclodextrin with its 8 glucose units, has a slightly larger cavity and can accomodate larger substrates than the beta form. The use of cyclodextrins in receptor binding assays in not recommended.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Chemical Synthesis||Solubilizing Agents||Cell Culture

Specifications
SKU 02153540-CF
Application Notes 2-Hydroxypropyl-beta-Cyclodextrin are non-toxic solubilizers. The solubility of drugs increases linearly with the concentration of 2-Hydroxypropyl-b-cyclodextrin in aqueous buffer. The formation of drug/cyclodextrin complexes is a rapidly reversible reaction and complexes exist both in solution and crystalline states. Solutions of many such complexes may be lyophilized to produce freely soluble powders which may be compressed into tablets. Bio-effects are only slightly affected by cyclodextrin complexation. Cells in serum supplemented medium can be grown in up to 1-2%. In serum-free medium, concentrations of 0.5-1% are acceptable. Hydroxypropyl-b-cyclodextrin has been found to be non-toxic in mice and rabbits. 2-hydroxypropyl-g-cyclodextrin with its 8 glucose units, has a slightly larger cavity and can accomodate larger substrates than the beta form. The use of cyclodextrins in receptor binding assays in not recommended.
EC Number 420-920-1
Format powder
Applications Chemical Synthesis||Solubilizing Agents||Cell Culture
Molecular Formula (C6H9O5)× • (C3H7O)×
Molecular Weight 1375.371 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description Hydroxypropyl β-cyclodextrin
Product Overview Hydroxypropyl Β-Cyclodextrin
Storage and Handling Room Temperature
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.