Endothelin 1

Endothelin 1

Synonyms Cys-Ser-Cys-Ser-Ser-Leu-Met- Asp-Lys-Glu-Cys-Val-Tyr-Phe- Cys-His-Leu-Asp-Ile-Ile-Trp; ET-1

CAS Number: 117399-94-7 Molecular Formula: C109H159N25O32S5 Molecular Weight: 2491.914 g/mol

MDL Number: MFCD00133305

Packaging size: 250 μg

SKU 02153092.2
Price:
$545.15
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Description

Product Description

Endothelin 1

Application Notes

Endothelin 1 has been used for coating wells in polystryene ELISA plates. Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1, for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Coating wells in polystryene ELISA plates

Specifications
SKU 02153092.2
Alternate Names Cys-Ser-Cys-Ser-Ser-Leu-Met- Asp-Lys-Glu-Cys-Val-Tyr-Phe- Cys-His-Leu-Asp-Ile-Ile-Trp; ET-1
Application Notes Endothelin 1 has been used for coating wells in polystryene ELISA plates. Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1, for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).
Biochemical Physiological Actions Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests.Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1a, and, thus, the production of VEGF.
Format powder
Applications Coating wells in polystryene ELISA plates
MDL # MFCD00133305
Molecular Formula C109H159N25O32S5
Molecular Weight 2491.914 g/mol
Pack Size 250 μg
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description Endothelin 1
Product Overview Endothelin 1
RTECS Number KE9446500
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.