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Caerulein, Sulfated

Caerulein, Sulfated

Synonyms pyroGlu-Gln-Asp-Tyr[SO3H]-Thr- Gly-Trp-Met-Asp-Phe-NH2; Caerulein Sulfated; Cerulein; Ceruletide; [Tyr(SO3H)4]Caerulein

CAS Number: 17650-98-5 Molecular Formula: C58H73N13O21S2 Molecular Weight: 1352.412 g/mol

Beilstein Registry Number: 5422487 MDL Number: MFCD00076478

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SKU 02152860-CF
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Description

Product Description

Caerulein, Sulfated

Application Notes

Caerulein is used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules such as NADPH oxidase and Janus kinase signal transducer. It prevents gall bladder pain, renal colic, and the pain of intermittent claudication.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules such as NADPH oxidase and Janus kinase signal transducer

Specifications
SKU 02152860-CF
Application Notes Caerulein is used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules such as NADPH oxidase and Janus kinase signal transducer. It prevents gall bladder pain, renal colic, and the pain of intermittent claudication.
Beilstein Registry Number 5422487
Biochemical Physiological Actions It is seen as an antagonist of endogenous opioids.
Format powder
Applications Used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules such as NADPH oxidase and Janus kinase signal transducer
Molecular Formula C58H73N13O21S2
Molecular Weight 1352.412 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
Preparation Method The peptide is to be dissolved in distilled, oxygen free or preferable sterile oxygen free water first. The concentration should be high enough to allow addition of buffer after the products is dissolved completely. If necessary diluted acetic acid or ammonium hydroxide, app. 1%, can be added to help solubilize the peptide. In those rare cases where solubilization is still not achieved, the solution may be sonicated briefly (up to 10 min, temperature shouldn't rise over 30-40 °C). In order to avoid serious solubility problems, buffer or saline should be added after the peptide is fully in solution.
Product Families Description Caerulein
Product Overview Caerulein, Sulfated
Solubility 1.16e-02 g/L
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.