Spectinomycin Dihydrochloride Pentahydrate

Spectinomycin Dihydrochloride Pentahydrate

Synonyms U18409AE; Actinospectacin; M141

CAS Number: 22189-32-8 Molecular Formula: C14H24N2O7 • 2HCl • 5H2O Molecular Weight: 495.344 g/mol

EC Number: 244-554-3 MDL Number: MFCD00150886

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SKU 02152067-CF
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Description

Product Description

Spectinomycin Dihydrochloride Pentahydrate

Application Notes

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotic||Treatment of gonorrhea||Selection agent for transformed plant cells

Specifications
SKU 02152067-CF
Alternate Names U18409AE; Actinospectacin; M141
Application Notes Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.
Biochemical Physiological Actions Mode of Action: Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (Gonnococcus only). Mode of Resistance: Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
EC Number 244-554-3
Format powder
Heavy Metals ≤0.005%
Applications Antibiotic||Treatment of gonorrhea||Selection agent for transformed plant cells
Loss on Drying <20%
MDL # MFCD00150886
Molecular Formula C14H24N2O7 • 2HCl • 5H2O
Molecular Weight 495.344 g/mol
Optical Rotation Positive
Personal Protective Equipment Eyeshields, Gloves, respirator cartridges
Physical Appearance White Powder
Potency ≥500 µg/mg
Product Families Description Spectinomycin
Product Overview Spectinomycin Dihydrochloride Pentahydrate
RTECS Number WG7400000
Source Streptomyces sp.
Storage and Handling Store at +4 °C.
Typical Working Concentration recommended for use in cell culture applications at 7.5-20 mg/L
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.