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Sodium Valproate

Sodium Valproate

Synonyms 2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate

CAS Number: 1069-66-5 Molecular Formula: C8H15NaO2 Molecular Weight: 166.196 g/mol

EC Number: 213-961-8 MDL Number: MFCD00078604

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SKU 02152064-CF
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Description

Product Description

Sodium Valproate

Application Notes

Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Anticonvulsant

Specifications
SKU 02152064-CF
Application Notes Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 μM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.
Biochemical Physiological Actions Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
Boiling Point 219.5 deg C
Density 0.904 g/cu cm at 25 deg C
EC Number 213-961-8
Format Crystalline powder
Hazard Statements H302
Applications Anticonvulsant
Molecular Formula C8H15NaO2
Molecular Weight 166.196 g/mol
Personal Protective Equipment Dust mask , Eyeshields, Gloves
Physical Appearance White Crystalline Powder
Product Families Description Sodium valproate
Product Overview Sodium Valproate
RTECS Number YV7876000
Safety Symbol GHS07
Solubility In <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>, 2.0X10+3 mg/L at 20 deg C
Storage and Handling Store at Room Temperature (15-30 °C).Store under nitrogen.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 8.47X10-2 mm Hg at 25 deg C (est)