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Phytohemagglutinin

Phytohemagglutinin

Synonyms PHA

CAS Number: 9008-97-3

EC Number: 232-718-7

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SKU 02151884-CF
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Description

Product Description

Phytohemagglutinin

Application Notes

In medicine PHA proteins are useful and are used as a mitogen to trigger T-lymphocytes cell division and to activate latent HIV-1 from human peripheral lymphocytes.The lectin has a number of effects on cell metabolism; it induces mitosis, and affects the cell membrane in regard to transport and permeability to proteins. It is used as positive control in ELIspot assay.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Agglutination

Specifications
SKU 02151884-CF
Application Notes In medicine PHA proteins are useful and are used as a mitogen to trigger T-lymphocytes cell division and to activate latent HIV-1 from human peripheral lymphocytes.The lectin has a number of effects on cell metabolism; it induces mitosis, and affects the cell membrane in regard to transport and permeability to proteins. It is used as positive control in ELIspot assay.
Biochemical Physiological Actions PHA consists of two molecular species, an erythroagglutinin (PHA-E) which has low mitogenic activity and high erythroagglutinin activity, and leucoagglutinin (PHA-L) which has high mitogenic and leucoagglutinating activity, but very low erythroagglutinating activity. PHA-E is not blood group specific, but agglutination can be inhibited by certain oligosaccharides. PHA-P is the protein form of PHA prior to separation and purification of erythroagglutinin and leucoagglutinin. PHA-M is the mucoprotein form. Conjugates are prepared from the corresponding purified lectins.
EC Number 232-718-7
Format Off-white Lyophilized Powder
Applications Agglutination
Physical Appearance White Lyophilized Powder
Product Families Description Phytohemagglutinin
Product Overview Phytohemagglutinin
Protein or Enzyme Type Lectins
RTECS Number TJ3470000
Source Red Kidney Beans (Phaseolus vulgaris)
Specific Activity Shows agglutination when tested with human red blood cells.
Storage and Handling 0°C
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.