Phorbol-12-Myristate-13-Acetate
Product Description
Phorbol-12-Myristate-13-Acetate
Application Notes
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Usage Statement
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications
Very Potent tumor promoter
| SKU | 02151864-CF |
| Alternate Names | Phorbol Acetate Myristate; Phorbol Monoacetate Monomyristate; PMA; 12-O-Tetradecanoylphorbol 13-acetate; 4,9,12,13,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; TPA |
| Application Notes | PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. |
| Beilstein Registry Number | 2407201 |
| Biochemical Physiological Actions | Potent tumor promoter; activates protein kinase C in vivo and in vitro. |
| Hazard Statements | H315 |
| Applications | Very Potent tumor promoter |
| MDL # | MFCD00036736 |
| Melting Point | 162° F (NTP, 1992) |
| Molecular Formula | C36H56O8 |
| Molecular Weight | 616.836 g/mol |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| Physical Appearance | Colorless Material |
| Product Families Description | Phorbol 12-myristate 13-acetate |
| Product Overview | Phorbol-12-Myristate-13-Acetate |
| Purity | >99% |
| RTECS Number | QH4377000 |
| Safety Symbol | GHS07 |
| Solubility | Practically insoluble (NTP, 1992) |
| Storage and Handling | Store at -20 °C. Protect from light. |
| Usage Statement | Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Vapor Pressure | 1.8X10-17 mm Hg at 25 deg C (est) |