Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
|Analysis Note||Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.|
|Application Notes||Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.|
|Biochemical Physiological Actions||Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)|
|Molecular Formula||C20H38N6O4 • 1/2H2SO4|
|Molecular Weight||951.196 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Physical Appearance||White Powder|
|Product Families Description||Leupeptin hemisulfate|
|Product Overview||Leupeptin Hemisulfate|
|Storage and Handling||Store at -20 °C; desiccate; protect from light.|
|Typical Working Concentration||Effective concentration 10-100 μM.|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|