Leupeptin Hemisulfate

Leupeptin Hemisulfate

Synonyms Acetyl-Leu-Leu-Arg-al

CAS Number: 103476-89-7 Molecular Formula: C20H38N6O4 • 1/2H2SO4 Molecular Weight: 951.196 g/mol

MDL Number: MFCD00037012

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SKU 02151553-CF
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Description

Product Description

Leupeptin Hemisulfate

Application Notes

Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibitor

Specifications
SKU 02151553-CF
Analysis Note Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.
Application Notes Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.
Biochemical Physiological Actions Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Applications Inhibitor
Molecular Formula C20H38N6O4 • 1/2H2SO4
Molecular Weight 951.196 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
Product Families Description Leupeptin hemisulfate
Product Overview Leupeptin Hemisulfate
Storage and Handling Store at -20 °C; desiccate; protect from light.
Typical Working Concentration Effective concentration 10-100 μM.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.