Hyaluronidase

Hyaluronidase

Synonyms Hyaluronate 4-glycanohydrolase; hyaluronate lyase; hyaluronoglucosaminidase; 3.2.1.35

CAS Number: 37326-33-3

EC Number: 253-464-3 MDL Number: MFCD00131351

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SKU 02151274-CF
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Description

Product Description

Hyaluronidase

Application Notes

Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated. Hyaluronidase is often used in conjunction with collagenase to dissociate the extracellular matrix between cells of animal tissue, in order to release viable cells for use in tissue culture. It may also be used to clarify synovial fluids in order to make cell counts possible.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Drug dispersion & delivery

Specifications
SKU 02151274-CF
Alternate Names Hyaluronate 4-glycanohydrolase; hyaluronate lyase; hyaluronoglucosaminidase; 3.2.1.35
Application Notes Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated. Hyaluronidase is often used in conjunction with collagenase to dissociate the extracellular matrix between cells of animal tissue, in order to release viable cells for use in tissue culture. It may also be used to clarify synovial fluids in order to make cell counts possible.
Biochemical Physiological Actions Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.
EC Number 253-464-3
Extinction Coefficient ~8
Format Lyophilized; salt free
Gene ID HYAL1, HYAL2
Hazard Statements H317
Applications Drug dispersion & delivery
MDL # MFCD00131351
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description Hyaluronidase
Product Overview Hyaluronidase
Source Ovine Testes
Specific Activity >1500 u/mg material
Specificity Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B); primarily to tetrasaccharide residues. Monosaccharides are not liberated.
Storage and Handling Store at -20 °C & dessicate.
Unit Definition Amount of enzyme which liberates one micromole of N-acetylglucosamine per minute at 37°C and pH 4.0
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.