Hyaluronidase from Steotomyces hyalurolyticus
Hyaluronidase is used to increase the absorption and dispersion of injected drugs or to disrupt the structure of certain organs.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
|Alternate Names||E.C. 18.104.22.168; Hyaluronate Glycanohydrolase; Hyaluronate lyase; Mucinase; EC 22.214.171.124|
|Application Notes||Hyaluronidase is used to increase the absorption and dispersion of injected drugs or to disrupt the structure of certain organs.|
|Biochemical Physiological Actions||Hyaluronidase splits the N-acetylglucosaminic linkages in hyaluronic acid eliminatively, yielding Δ-4,5-unsaturated tetrasaccharides and hexasaccharides as the end-product.|
|Foreign Activity||Protease: Not Detectable; Lysozyme: Not Detectable; Salt: Not Detectable|
|Physical Appearance||White Lyophilized Powder|
|Product Families Description||Hyaluronidase|
|Specific Activity||~2000 u/mg|
|Specificity||Hyaluronidase purified from Streptomyes hyalurolyticus is distinct from the known hyaluronidase in its substrate specificity and mechanism of action. This enzyme is quite specific for hyaluronic acid. Various types of chondroitin sulfate (A;B;C;D;;E); chondroitin; heparin; keratan sulfate and chitin are not attacked by this enzyme.|
|Storage and Handling||+4 °C|
|Unit Definition||Enzyme activity is determined by a change in optical density in a solution of hyaluronic acid. Activity is compared to a hyaluronidase International Standard and is expressed as an International Unit (U).|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|