Fibrinogen Fraction I

Fibrinogen Fraction I

Synonyms Factor 1

CAS Number: 9001-32-5 Molecular Weight: 182.172 g/mol

EC Number: 232-598-6 MDL Number: MFCD00163624

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SKU 02151122-CF
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Description

Product Description

Fibrinogen Fraction I

Application Notes

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Clotting Factor||Enzymes||Inhibitors||Substrates

Specifications
SKU 02151122-CF
Alternate Names Factor 1
Application Notes Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).
Biochemical Physiological Actions Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
EC Number 232-598-6
Gene ID cow ... FGA(522039), FGB(510522), FGG(280792)
Applications Clotting Factor||Enzymes||Inhibitors||Substrates
MDL # MFCD00163624
Moisture Content ≤10%
Molecular Weight 182.172 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance White Flaky Powder
Product Families Description Fibrinogen
Product Overview Fibrinogen Fraction I
Purity Protien content ~75%
Source Bovine Plasma
Storage and Handling -20°C
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.