Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate

Synonyms Endoxan A; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; N,N-bis(2-Chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate; 2-[bis(2-Chloroethyl) amino] tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate; 1-bis(2-Chloroethyl) amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate; bis(2-Chloroethyl) phosphamide cyclic propanolamide ester monohydrate; bis(2-Chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; N,N-bis(b-Chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate; N,N-bis(b-Chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate; Cyclophosphane; Cytophosphane; B-518

CAS Number: 6055-19-2 Molecular Formula: C7H15Cl2N2O2P · H2O Molecular Weight: 279.098 g/mol

Beilstein Registry Number: 4678992 EC Number: 200-015-4 MDL Number: MFCD00149395

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SKU 02150749-CF
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Description

Product Description

Cyclophosphamide Monohydrate

Application Notes

Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Cancer research tool

Specifications
SKU 02150749-CF
Alternate Names Endoxan A; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; N,N-bis(2-Chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate; 2-[bis(2-Chloroethyl) amino] tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate; 1-bis(2-Chloroethyl) amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate; bis(2-Chloroethyl) phosphamide cyclic propanolamide ester monohydrate; bis(2-Chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; N,N-bis(b-Chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate; N,N-bis(b-Chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate; Cyclophosphane; Cytophosphane; B-518
Application Notes Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported.
Beilstein Registry Number 4678992
Biochemical Physiological Actions Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
EC Number 200-015-4
Flash Point greater than 230° F (NTP, 1992)
Hazard Statements H301-H350
Applications Cancer research tool
MDL # MFCD00149395
Melting Point 121 to 127° F (NTP, 1992)
Molecular Formula C7H15Cl2N2O2P · H2O
Molecular Weight 279.098 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Physical Appearance White Crystalline Powder
Product Families Description Cyclophosphamide
Product Overview Cyclophosphamide Monohydrate
Purity ≥98%
RTECS Number RP6157750
Safety Symbol GHS06, GHS08
Solubility 10 to 50 mg/mL at 73° F (NTP, 1992)
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.