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Cephalexin Monohydrate

Cephalexin Monohydrate

Synonyms 7-(d-a-Aminophenylacetamido)desacetoxycephalosporanic acid; Cefalexin monohydrate; [6R-[6α,7β(R*)]]-7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid monohydrate; 7-(Dα-aminophenylacetamido) desacetoxycephalosporanic acid monohydrate

CAS Number: 23325-78-2 Molecular Formula: C16H17N3O4S·H2O Molecular Weight: 365.404 g/mol

Beilstein Registry Number: 965503 EC Number: 239-773-6 MDL Number: MFCD00167148

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SKU 02150585-CF
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Description

Product Description

Cephalexin Monohydrate

Application Notes

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin and other antibiotics have been shown to inhibit p-aminohippurate uptake by the rat renal organic anion transporter 1, as expressed in Xenopus laevis oocytes. A study of CHO cells transfected with the vector for the H+-coupled peptide transporter PEPT1 has shown that cephalexin is a competitor for dipeptide transport. Cephalexin has been used to culture E. coli at 10 µg/mL for the expression of fusion proteins.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibacterial||Antibiotics

Specifications
SKU 02150585-CF
Application Notes Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin and other antibiotics have been shown to inhibit p-aminohippurate uptake by the rat renal organic anion transporter 1, as expressed in Xenopus laevis oocytes. A study of CHO cells transfected with the vector for the H+-coupled peptide transporter PEPT1 has shown that cephalexin is a competitor for dipeptide transport. Cephalexin has been used to culture E. coli at 10 µg/mL for the expression of fusion proteins.
Beilstein Registry Number 965503
Biochemical Physiological Actions Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
Certifications Meets B.P. and U.S.P. specifications
EC Number 239-773-6
Extinction Coefficient 7.75(Lit.)
Format powder
Grade B.P. and U.S.P. Grade
Hazard Statements H317-H334
Applications Antibacterial||Antibiotics
Melting Point 326.8 °C
Molecular Formula C16H17N3O4S·H2O
Molecular Weight 365.404 g/mol
Optical Rotation +149° to +158° (pH 4.4)
Personal Protective Equipment Dust mask , Eyeshields, Faceshields, Gloves
Physical Appearance White Powder
pKa 5.2, 7.3(Lit.)
Potency 950 - 1010 µg/mg (anhydrous basis)
Product Families Description Cephalexin monohydrate
Product Overview Cephalexin Monohydrate
Purity ≥95%
RTECS Number XI0350000
Safety Symbol GHS08
Solubility Water Solubility1.789 mg/mL as monohydrate salt (solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty)
Storage and Handling Store at +4 °C; desiccate.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance 260 - 262 nm (water)