Blasticidin S Hydrochloride

Blasticidin S Hydrochloride

Synonyms BLA-S; Cytovirin; Blasticidine S hydrochloride; 4-[[3-Amino-5-[(aminoiminomethyl)-1-oxopentyl]amino]-1-(4-amino-2-oxo- 1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-b-D-erythro-hex-2-enopyranuronic acid

CAS Number: 589205 Molecular Formula: C17H26N8O5 • HCl

MDL Number: MFCD02091640

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SKU 02150477-CF
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Description

Product Description

Blasticidin S Hydrochloride

Application Notes

Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells. It is also used to study protein synthesis at the level of peptide bond formation.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antimicrobial

Specifications
SKU 02150477-CF
Alternate Names BLA-S; Cytovirin; Blasticidine S hydrochloride; 4-[[3-Amino-5-[(aminoiminomethyl)-1-oxopentyl]amino]-1-(4-amino-2-oxo- 1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-b-D-erythro-hex-2-enopyranuronic acid
Application Notes Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells. It is also used to study protein synthesis at the level of peptide bond formation.
Biochemical Physiological Actions Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.
Hazard Statements H300
Applications Antimicrobial
MDL # MFCD02091640
Molecular Formula C17H26N8O5 • HCl
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator , Gloves, respirator filter, respirator cartridges
Physical Appearance White Powder
Product Families Description Blasticidin S
Product Overview Blasticidin S Hydrochloride
RTECS Number EC4900000
Safety Symbol GHS06
Source Streptomyces griseochromogenes
Storage and Handling +4°C; desiccate
Typical Working Concentration Typically used at 2 - 10 µg/mL for mammalian cell selection.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.