5-Fluorodeoxyuridine

5-Fluorodeoxyuridine

Synonyms 2'-Deoxy-5-Fluorouridine; Floxuridine; 5-Fluoro-2'-deoxyuridine; FUDR; dFUR

CAS Number: 50-91-9 Molecular Formula: C9H11FN2O5 Molecular Weight: 246.194 g/mol

Beilstein Registry Number: 90221 EC Number: 200-072-5 MDL Number: MFCD00006530

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SKU 02105551-CF
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Description

Product Description

5-Fluorodeoxyuridine

Application Notes

5-Fluorodeoxyuridine can be used to target thymidylate synthetase in cancer chemotherapy. Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Chemotherapy

Specifications
SKU 02105551-CF
Application Notes 5-Fluorodeoxyuridine can be used to target thymidylate synthetase in cancer chemotherapy. Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
Beilstein Registry Number 90221
Biochemical Physiological Actions Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase. Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.
EC Number 200-072-5
Extinction Coefficient EmM = 8.91 (0.1 M phosphate buffer, pH 6.0) (Lit.)
Format powder
Hazard Statements H301
Applications Chemotherapy
Melting Point 302 to 304° F (NTP, 1992)
Molecular Formula C9H11FN2O5
Molecular Weight 246.194 g/mol
Optical Rotation +37 ° (10 mg/mL in water at 25 °C) (Lit.)
Personal Protective Equipment Dust mask , Eyeshields, Faceshields, Gloves
Physical Appearance White powder
pKa 7.6 (Lit.)
Product Families Description 5-Fluorodeoxyuridine
Product Overview 5-Fluorodeoxyuridine
Purity >98%
RTECS Number YU7525000
Safety Symbol GHS06
Solubility Water Solubility11900 mg/L
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λmax (water) : 266 - 270 nm
Vapor Pressure 7.6X10-13 mm Hg at 25 deg C (est)