Actinomycin D

Actinomycin D

Synonyms Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; Meractinomycin; Actinomycin AIV; Actinomycin IV; Actinomycin C1; Actinomycin X1; NSC-3053; Cosmegen

CAS Number: 50-76-0 Molecular Formula: C62H86N12O16 Molecular Weight: 1255.438 g/mol

Beilstein Registry Number: 605235 EC Number: 200-063-6 MDL Number: MFCD00005033

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SKU 02104658-CF
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Description

Product Description

Actinomycin D

Application Notes

Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Selection agent||antineoplastic antibiotic

Specifications
SKU 02104658-CF
Alternate Names Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; Meractinomycin; Actinomycin AIV; Actinomycin IV; Actinomycin C1; Actinomycin X1; NSC-3053; Cosmegen
Application Notes Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Beilstein Registry Number 605235
Biochemical Physiological Actions Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
EC Number 200-063-6
Format Crystalline powder
Hazard Statements H300
Applications Selection agent||antineoplastic antibiotic
MDL # MFCD00005033
Melting Point 467 to 469° F (decomposes) (NTP, 1992)
Molecular Formula C62H86N12O16
Molecular Weight 1255.438 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
Physical Appearance Red Crystalline Powder
Product Families Description Actinomycin D
Product Overview Actinomycin D
Purity ~98%
RTECS Number AU1575000
Safety Symbol GHS06
Solubility Soluble at 50° F (NTP, 1992)
Source Streptomyces parvalus
Storage and Handling Store at +4 °C; protect from light
Typical Working Concentration 1 µg/mL
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 0 mm Hg at 25 deg C (est)